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Home page > News > MLST investigation within the Brucella genus

MLST investigation within the Brucella genus

Whatmore et al. have investigated the genetic diversity and phylogeny of the Brucella genus by multiple loci sequence typing. More than 4 kb of sequence were examined from 160 isolates. 27 sequence types can be distinguished. The clustering achieved confirms the close vicinity of B. canis with B. suis biovar 3 and 4, and the marked difference with B. suis biovar 5. The marine strains are tightly clustered by this approach. Although much less discriminatory than MLVA, MLST data provides a squeleton which will help define the relative weight which should be given to MLVA loci to provide an optimized clustering.