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MLVA analysis of Brucella isolates from human patients

Al Dahouk et al. published an MLVA investigation of Brucella isolates from human patients. One hundred and twenty-eight isolates were recovered from patients from France and Germany. Most cases were imported events, resulting from travels in mediterranean countries. MLVA patterns reflect to some extend the geographic origin of the isolates, when it can be deduced from the epidemiological investigation. The authors propose three main clusters, “East-Mediterranean”, “West-Mediterranean”, and “Americas”. The MLVA assay used was based upon Le Flèche 2006, complemented by a new valuable marker, Bruce 19. The sixteen loci are divided into three panels, panel 1 (8 loci), panel 2A and panel 2B (4 loci each). Each panel is given a different weight in clustering analysis, to reflect a different level of homoplasy at these loci.